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Tofacitinib is a prescription medication called a janus kinase (JAK) inhibitor. It is a disease modifying anti-rheumatic drug (DMARD), which works by suppressing the immune system. Tofacitinib is available in the form of a tablet (Xeljanz), an extended release tablet (Xeljanz XR) and as an oral solution.
It is used to treat certain inflammatory conditions in people who have already tried tumor necrosis factor (TNF) blockers.
When tofacitinib was approved by the FDA in 2012, it was the first approved JAK inhibitor for the treatment of rheumatoid arthritis and also the first new oral DMARD to be approved for the condition in more than a decade.