Cyproheptadine is a serotonin and histamine antagonist with property. It finds clinical application in stimulating the appetite and growth. The appetite stimulating effect of cyproheptadine is probably a consequence of serotonin antagonism. It antagonizes the satiety stimulating effects of serotonin on the satiety center. Weight gain and increased growth in children that have been observed with cyproheptadine can be attributed to an interference with regulation of the secteation of growth hormone.Tricholine citrate contains three molecules of choline. Clinical interest in choline centers of its lipotropic action & its utility in the treatment of fatty infiltration and cirrhosis of liver. Choline converts fat into phospholipids like, lecithin, which is essential to biomembrane structure and its function. Lecithin is also a major component of high density lipoprotein and is used to mobilize cholesterol from cell membrane. In patients with fatty liver, increased rate of phospholipid turnover has been observed following administration of choline. DOSAGE 1 tablespoonful twice a day INDICATIONS Loss of appetiteWeight lossAnorexia nervosa SIDE EFFECTS These may include sedation, dizziness, disturbed coordination, confusion, restlessness, rashes, urticaria, blurred vision, diplopia, vertigo, tinnitus, hypotension, palpitation, tachycardia, dryness of mouth, anorexia, diarrhea, constipation, and urinary retention, dryness of nose and throat and thickening of bronchial secreations. DRUG INTERACTIONS MAO inhibitors prolong and intensify the anticholinergic effects of antihistamines. It may have additive effects with alcohol and other CNS depressants like, hypnotics, , tranquilizes and antianxiety agents.