C-95 obtained from the dried rhizomes of Curcuma longa(Turmeric) and standardized for minimum 95% Curcuminoids. The name C3 Complex has reference to its three main chemical compounds - Curcumin, Demethoxycurcumin (DMC) and Bisdemethoxycurcumin (BDMC) Curcumin c3 complex Nutraceutical applications Antioxidant Anti-inflammatory support Immune support Plant part used Root Beneficial Effects of Curcuminoids Curcumin C3 Complex is an effective "Bioprotectant, antioxidant quenching free radicals and also preventing their formation1 Curcumin has been shown to be a COX-2 (Cyclooxygenase-2) inhibitor1 Unlike conventional non steroidal anti-inflammatory drugs (NSAIDs), curcuminoids do not cause gastrointestinal side effects or ulcers Curcuminoids support a healthy immune system1 Prevent connective tissue break down through inhibiting destructive enzymes2 Nutraceutical Applications of Curcuminoids Antioxidant support Alzheimers disease/dementia Cardiovascular support Immune support/Anti-tumor/Anticancer effects, Anti-inflammatory support Wound healing For example: Rheumatoid arthritis, postoperative inflammation, colorectal cancer, bladder cancer, oral leucoplakia, psoriasis, antiviral effects Pharmacology & Clinical Trials Curcumin/Piperine - IND study approved: IND# 61,872 Food & Drug Administration Office of Drug Evaluation I, Division of Oncology Drug Products The effects of Curcuminoids on aberrant crypt foci in the human colon: IND# 51,685 UMDNJ- Robert Wood Johnson Medical School, New Jersey Cancer Institute Pilot study of curcuminoids with or without BioPerine in patients with multiple myeloma: IND# 67,963 MD Anderson Cancer Center, University of Texas Prevention and intervention ofAlzheimer''''s disease with curcuminoids: - University of California, Los Angeles Curcuminoids in patients with Lichen planus: IND#65,700/S-000 - University of California Phase IIa prevention study of C3 Complex curcuminoids in women at increased risk for breast cancer MD Anderson Cancer Center, University of Texas The clinical and laboratory effects of topical curcuminoids in patients with normal skin and with dysplastic and benign nevi National Cancer Institute Phase II prevention study with C3 Complex in patients with colorectal cancer stage I-III Lincoln Medical and Mental Health Center, Bronx, NY Phase I trial of C3 Complex and precooperative patients with locally advanced esophageal or gastroesophageal carcinoma MD Anderson Cancer Center, University of Texas Metabolic studies and chemopreventive studies -University of Leicester, Uk