3-Amino Acetophenone, C8H9NO, CAS No. 99-03-6
| Chemical Name | 3-Amino Acetophenone |
| CAS Number | 99-03-6 |
| Molecular Formula | C8H9NO |
| Purity | 97%, 98%, >98% |
| Packaging Details | 25 kg Bag, 35 kg Drum, 50 kg Drum |
| Synonyms | 3-Acetylaniline, 3-Aminoacetofenon, m-Aminoacetylbenzene, 3-Acetylphenylamine |
Chemical Identifiers
| Chemical Name | 3-Amino Acetophenone |
| CAS Number | 99-03-6 |
| Molecular Formula | C8H9NO |
| Synonyms | 3-Acetylaniline, 3-Aminoacetofenon, m-Aminoacetylbenzene, 3-Acetylphenylamine |
| EC Number | 202-722-3 |
| IUPAC Name | 1-(3-aminophenyl)ethanone |
General Details
| Purity | 97%, 98%, >98% |
| Packaging Details | 25 kg Bag, 35 kg Drum, 50 kg Drum |
Chemical Properties
| Molecular Weight (g/mol) | 135.16 g/mol |
| Density | 1.103 g/mol |
| Melting Point | 98°C |
| Boiling Point | 290°C |
| Solubility in water | 7.06 g/L |
| Acidity (pKa) | 3.41 |
| Refractive index | 1.57 |
| Flash Point | 130°C |
| Surface tension | 44.3 N/m |
| Critical Temperature | 401°C |
| Critical Pressure | 4.16 Mpa |
| Dipole Moment | 1.90 D |
| Heat of Fusion | 16.92 kJ/mol |
| Heat of Vaporization | 53.73 kJ/mol |
| Heat of Combustion | -4261 kJ/mol |
| Storage Temperature | 2 to 8°C |
Physical Properties
| Physical Form | Powder |
| Color | Yellow to Light brown |
| Odor | Pleasant |
| Shelf Life | 5 Years |
- Used in food industry as a biomarker
- It can also be used as a catalyst
- Used as a reagent
- Used as a flavouring agent
- Used in the synthesis of anti bacterial drugs
Production of 3-Amino Acetophenone
Continuous tubular reactor based conversion of acetophenones to amino substituted acetophenones wherein the nitration is carried out at -10 to 10 °C followed by reduction to m-nitrophenone resulting in uniform output of product, said process comprising the steps of Nitrating acetophenone with nitrating agent (nitration mixture or fuming nitric acid) at -10 to 10 °C, Isolating m-nitro acetophenone from a mixture of o and m-nitro acetophenone and Reducing the m-nitro to obtain m-amino acetophenone.
ASTM Testing Standard
• D5116 Standard Guide for Small Scale Environmental Chamber Determinations of Organic Emissions from Indoor Materials / Product
• D6670 Standard Practice for Full-Scale Chamber Determination of Volatile Organic Emissions from Indoor Materials / Products
• D5197 Test Method for Determination of Formaldehyde and Other Carbonyl Compounds in Air
• D6196 Practice for the Selection of Sorbents and Pumped Sampling / Thermal desorption Analysis Procedures for Volatile Organic Compounds in Air
• D6345 Standard Guide for Selection of Methods for Active, Integrative Sampling of Volatile Organic Compounds in Air
• E741 Standard Test Method for Determining Air Change in a Single Zone by Means of a Tracer Gas Dilution
Storage and Handling
• Handling Avoid contact with skin and eyes. Do not breathe dust. Do not ingest. If swallowed then seek immediate medical assistance.
• Storage Keep in a dry, cool and well-ventilated place. Refer product specification and/or product label for specific storage temperature requirement. Keep container tightly closed.
Incompatible Materials
Strong oxidants
Fire Fighting
• As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
• Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate foam.
First Aid
• Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
• Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
• Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Do not induce vomiting.
• Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid
Hazard Statement
• Harmful if swallowed
• Eye: May cause eye irritation. May cause chemical conjunctivitis.
• Skin: Causes mild skin irritation. May be harmful if absorbed through the skin.
• Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May be harmful if swallowed. May form methemoglobin which in sufficient concentration causes cyanosis.
• Inhalation: May cause cyanosis. Causes irritation of the mucous membrane and upper respiratory tract
Precaution
• Exposure Guidelines This product does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies
• Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by eye and face protection regulations
• Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure. Respiratory Protection No protective equipment is needed under normal use conditions. Hygiene measures Handle in accordance with good industrial hygiene and safety practice
Uses
3'-Aminoacetophenone has potential anti-bacterial properties in addition to being used in the synthesis of selective antagonists at human A2B adenosine receptors. As well, it is used in the synthesis of HIV-1 Integrase Inhibitors. It is used as starting reagent during the synthesis of curcumin mimics with substituted sulfonyl group.